Affiliated Faculty Information

I. Affiliated Faculty, Lerner Research Institute, Cleveland Clinic

 Ashok Agarwal, Ph.D.  Biological markers of oxidative stress; proteomic  and bioinformatics in DNA damage, apoptosis and preserving fertility in patients with cancer; laboratory and clinical studies assessing efficacy of certain antioxidants in improving male fertility

Alex Almassan, Ph.D.  Autophagy; apoptosis; cell cycle; DNA damage; ubiquitin; DNA repair; cancer therapeutics; radiation therapy; leukemia; epithelial tumors; prostate cancer

Suneel Apte, M.B.B.S, Ph.D.  Extracellular matrix; proteolysis; metalloproteinases; ADAMTS proteases; ADAMTS-like proteins; proteomics; morphogenesis; cardiovascular; musculoskeletal; birth defects; fetal-maternal medicine; eye disorders; neural tube; craniofacial development; smooth muscle; post-translational modification; inherited connective tissue disorders; osteoarthritis; primary cilium

Mark Aronica, M.D.  Mechanisms by which specific ECM proteins contribute to the onset of asthma

Kathleen Berkner, Ph.D.  Vitamin K; vitamin K-dependent protein carboxylation; hemostasis; anticoagulation; calcification; vitamin K-dependent clotting factors deficiency (VKCFD); pseudoxanthoma elasticum; warfarin resistance; gamma-glutamyl carboxylase; vitamin K oxidoreductase (VKOR)

Mark Brown, Ph.D.  Lipid metabolism; lipoprotein metabolism; atherosclerosis; obesity; diabetes; reverse cholesterol transport; triacylglycerol; nutrition

Tatiana Byzova, Ph.D.  Angiogenesis; endothelial cells; integrins; extracellular matrix; cell adhesion; tumor progression; vascular biology; signal transduction in endothelium and platelets; oxidative stress and vasculature; toll-like receptors in angiogenesis

John Crabb, Ph.D.  Eye; age-related macular degeneration; glaucoma; uveal melanoma; proteomics

Donna Driscoll, Ph.D.  RNA biology; mRNA translational control; nutritional regulation of gene expression; selenium

Serpil Erzurum, M.D.  Asthma; pulmonary vascular disease; hypoxia; metabolism

Paul Fox, Ph.D.  Angiogenesis; atherosclerosis; cell migration; endothelial cells; iron metabolism; macrophages; translational control

Vincent Hascall, Ph.D.  Hyaluronan in inflammation; asthma; diabetes; autophagy; hyperglycemia; connective tissue biology

Stanley Hazen, M.D., Ph.D.  Inflammation; atherosclerosis; asthma; myeloperoxidase; cardiovascular diseases; HDL; peroxidases; airway remodeling; intestinal microbiota; gut flora; cardiometabolic disease

Christopher Hine, Ph.D.  Dietary restriction; aging; lifespan extension; stress resistance; exercise; hydrogen sulfide (H2S) production and metabolism; sulfur amino acid metabolism; endocrine signaling and longevity

Sadashiva Karnik, Ph.D.  GPCRs; angiotensin receptors; ARBs; biased signaling; cardiac hypertrophy; hypertension; heart failure; structure-function of GPCRs; transmembrane signaling; microRNA; gene expression; chromatin protein modifications; STAT3 and U-STAT3 signaling; RGS proteins

Xiaoxia Li, Ph.D.  Signal transduction in innate and adaptive immunity

Daniel Lindner, M.D., Ph.D.  Mechanisms of acquired drug resistance in renal cancer, development of more effective drugs to treat myelodysplastic syndrome and acute myelogenous leukemia

Thomas McIntyre, Ph.D.  Lipid mediators; inflammatory signaling; platelet biology; biochemistry; acute kidney injury

Richard Padgett, Ph.D.  Transcription; RNA processing; RNA splicing; splicing factors; relation to cancer and developmental diseases; gene structure and function; genomics; evolution of genomes; RNA biochemistry

Edward Plow, Ph.D.  Integrins; plasminogen; kindlins; thrombospondins; atherothrombosis

Eugene Podrez, M.D., Ph.D.  Atherosclerosis; thrombosis; atherothrombosis; platelets; macrophage; scavenger receptors; LDL; HDL; cholesterol; phospholipids; oxidative stress; lipid peroxidation

Jun Qin, Ph.D.  Signal transduction; integrin; cell adhesion; cell migration; kinase; heart disease; cancer; structural biology; protein NMR; protein crystallography

Sujata Rao, Ph.D.  Eye; developmental biology; circadian clock; neurovascular development; thyroid hormone signaling; cone photoreceptors; vascular remodeling

Nima Sharifi, M.D.  Prostate cancer; androgens; metabolism; steroids; castration-resistant prostate cancer; androgen receptor; hormone therapy; medical oncology; dihydrotestosterone; enzymes; biochemistry

Robert Silverman, Ph.D.  Interferon; rnase l; antiviral innate immunity; oncolytic virotherapy, DNA methyltransferase inhibitor

Jonathan Smith, Ph.D.  Atherosclerosis; HDL metabolism; atrial fibrillation; genetics; genomics; eQTL; gene expression; reverse cholesterol transport; dysfunctional HDL; RNAseq; allelic expression imbalance; ABCA1; mouse models; zinc finger nuclease

George Stark, Ph.D.  Interferons; IL-6; NFkB; STAT3; EGFR; drug resistance; DNA repair; lung cancer; breast cancer; prostate cancer; glioblastoma; septic shock

Dennis Stuehr, Ph.D.  Inflammation; nitric oxide; heme transport; soluble guanylate cyclase; electron transfer

Wai Hong Wilson Tang, M.D.  Heart failure; cardiomyopathy; nitrative stress; metabolomics; cardio-renal syndrome

Bruce Trapp, Ph.D.  Multiple sclerosis; glia; oligodendrocytes; astrocytes; neuroprotection; myelin, autism

​​​​​​​Qingyu Wu, M.D., Ph.D. Blood pressure; cardiac function; cardiovascular disease; cell membrane proteases; corin; hormone processing; hypertension; preeclampsia; pregnancy-induced hypertension; proteolytic enzymes; vascular biology 

Bin Zhang, Ph.D.  Mechanism of intracellular trafficking in human disease development; protein secretion; endoplasmic reticulum stress; hemophilia; alpha-1-antitrypsin deficiency, cardiovascular diseases; cancer

II. Affiliated Faculty, Doctoral Clinical Laboratory Scientists             

A. Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic

Edmund Z. Reineks, M.D., Ph.D., DABCC   Point of care testing; quality; lab directorship; special topics

Adam McShane, Ph.D., DABCC  Automated chemistry; cardiovascular disease; blood gases

Marvin Natowicz, M.D., Ph.D.   Biochemical genetics; metabolic diseases

Manjula Gupta, Ph.D.  Cancer; endocrinology

Jessica Colon-Franco, Ph.D., DABCC  Endocrinology; special chemistry; leadership

Kamran Kadkhoda, Ph.D., DABMLI  Immunopathology; serology; allergy; cellular immunology

Grace Kroner, Ph.D.  Special chemistry; diabetes testing; laboratory test utilization; data analytics

B. Department  of Pathology, MetroHealth Medical Center

Michael Ip, Ph.D., DABCC   Clinical chemistry; endocrinology; prenatal diagnosis; infertility; POCT; clinical toxicology; critical care lab; rapid response labs

C. Department of Pathology and Laboratory Medicine, Children’s Hospital Medical center of akron

Sihe Wang, Ph.D., DABCC  General clinical chemistry; pediatric testing; chromatography; mass spectrometry; assay development; CLIA regulation; laboratory management; process improvement

D. Quest Diagnostics Cleveland HeartLab Center of Excellence

Deborah Sun, Ph.D.   Clinical laboratory operations and management

III. Affiliated Faculty Case Western Reserve University or MetroHealth/Case Western Reserve University

(*Faculty with primary position at MetroHealth Medical Center) 

Romani Andrea M.D., Ph.D.   Regulation of magnesium homeostasis and transport in mammalian cells

Ge Jin, Ph.D.   Mechanism of cancer cell-derived cytokines and/or metabolites; immune response and role of HIV-infection in development/progression of non-AIDS-defining cancers

*Jeffrey Schelling, M.D. (MetroHealth Medical Center/Case Western Reserve University)  Mechanisms of chronic kidney disease progression; in vitro molecular and cellular methods, animal models and human studies investigating glomerular and tubulointerstitial pathophysiology

*Bing-Cheng Wang, Ph.D.  (MetroHealth Medical Center/Case Western Reserve University)  Roles of Eph receptor tyrosine kinases in invasive growth and distal metastasis of cancer cells

Wen-Quan Zou, M.D., Ph.D.   Protein aggregation in the conformational diseases; pathologic prion proteins (PrPC and PrPSc) in prion diseases (PrD); neurotoxic amyloid β (Aβ) in Alzheimer disease (AD); Creutzfeldt-Jakob disease (CJD)

IV. Affiliated Faculty, Cleveland State University

Jerry Mundell, Ph.D.    Manager, Freshman Chemistry Program, Department of Chemistry

V. Affiliated Faculty, NASA

James L. Smialek Ph.D.  High temperature oxidation; coatings